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What must the immune system utilize to turn on the genes for apoptosis?

The immune system and apoptosis work together to kill cancer cells.

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1. utilise some genes like tumor supresor genes or oncogenes..
2. In order for cells to respond to their environment, external stimuli must be received and transmitted to the nucleus. This results in activation of genes that lead to specific biologic responses. STAT proteins are normal constituents of cells, the acronym standing for signal transduction and translation. The STAT proteins are a point of convergence for numerous signaling pathways that lead to cancer. Although there are seven STAT proteins, STAT-3 is the most commonly found in a large variety of cancers. The signal transduction phase begins with a growth factor or cytokine binding to their specific receptors on the cell membrane. This results in the activation of enzymes called tyrosine kinases, which in turn activate the STAT proteins. In the translation phase, the STAT protein migrates to the nucleus, where it binds to promoter elements on the DNA molecule, leading to expression of target genes.
3. Some activators/capsases such as Ced-3 ced-4 and ced-9 are bound in the mitochondrial membrane until certain genes are turned on, in humans , P53 is responsible and it thought to eb the gate keeper gene because it casues most of the regulatory pathways for cell mediated apoptosis. (Ced's are from the nematode C.elegans, its homolog for P53 is Cep-1) It depends on the damage to the cell or if it was the cell fate , but certain pathways are initiated and usually a complex of strong capase or kinases are formed and cell death occurs.