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How does cyclosporin affect the immune system?

What cells types does it affect (more specific than just white blood cells), how does it counteract the immune system's processes?

Public Comments

1. well,cyclosporin is thought to bind to the cytosolic protein cyclophilin (immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes this will lead to : 1- this complex of ciclosporin and cyclophylin inhibits calcineurin, which under normal circumstances is responsible for activating the transcription of interleukin-2. 2- it also inhibits lymphokine production and interleukin release and therefore leads to a reduced function of effector T-cells. 3-it has also an effect on mitochondria. 4- cyclosporin A prevents the mitochondrial PT pore from opening and inhibits thus cytochrome c release, a potent apoptotic stimulation factor.
2. http://www.pharma.ca.novartis.com/downloads/en/products/neoral_patient_e.pdf#search='cyclosporine%20affect%20immune%20system' it gives all the information you need. good luck
3. Cyclosporin is the drug that made human organ transplants a going concern. Prior to its development, transplantation was limited to kidneys between twins. Cyclosporin suppresses the immune system in order to prevent organ rejection. Cyclosporin is an older drug and is not used as much on more recent transplant recipients. I recieved my transplant nearly nine years ago and have never used cyclosporin, Newer drugs such as prograf and cell-cept are more targeted to suppress only the aspects of the immune system that mediates rejection. The newere drugs have a reduced risk of allowing other infections to occur and are generally safer.